MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective
نویسندگان
چکیده
منابع مشابه
Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation
Fragile X syndrome (FXS) is caused by CGG repeat expansion that leads to FMR1 silencing. Women with a premutation allele are at risk of having a full mutation child with FXS. To investigate the mechanism of repeat expansion, we examined the relationship between a single-nucleotide polymorphism (SNP) variant that is linked to repeat expansion in haplogroup D and a replication origin located ∼53 ...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2018
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007719